Vitamin b12 and folate relationship counseling

B vitamins may ward off depression and other mental health problems. Low Sexual Desire · Relationships · Sex . When researchers followed up with patients six months after counseling sessions had ended, people whose B12 levels B12 and folate, or folic acid, helps rid the body of homocysteine. Specifically, B12 and folic acid (or folate) are making headlines for their roles in and B-vitamins is homocysteine levels, but the relationship is intriguing. mentioned above, it is worth consulting with your physician and/or a. The effects of vitamin B12 deficiency are widespread. Vitamin B12 has a major influence on the function of neurons and also on the ability of the bone marrow to .

Folic acid with or without vitamin B12 for cognition and dementia.

Folate deficiency-related macrocytic anemia is due to failure of precursor blood cells to divide because of a lack of DNA. Vitamin B acts as a cofactor for methionine synthase MSwhich catalyzes the remethylation of homocysteine to methionine. Hyperhomocysteinemia is another consequence of deficiencies of either folate or vitamin B 2.

This effect is due, in part, to the requirement by MS for both folate and vitamin B S-adenosylmethionine also serves as the sole methyl donor for the central nervous system, which may explain associations between folate deficiency and vitamin B deficiency and cognitive impairment and mental illness 34. One of the most devastating consequences of vitamin B deficiency is a classic neuropathy called combined degeneration of the spinal cord 5.

vitamin b12 and folate relationship counseling

The mechanism by which vitamin B deficiency leads to this fatal demyelinating illness is unknown, but its specific link to vitamin B deficiency, but not folate deficiency, may provide a clue to the causal pathway.

Another unique consequence of vitamin B deficiency relates to its role in the isomerization of L-methylmalonyl—coenzyme A CoA to succinyl-CoA—a reaction that, unlike the remethylation of homocysteine, occurs in the mitochondria and does not involve folate. Thus, vitamin B deficiency specifically results in increased methylmalonic acid MMA concentrations in both plasma and urine.

Pernicious anemia and excessive intake of folic acid After studying malnourished pregnant women in India in the late s, Lucy Wills described a macrocytic anemia that shared some features with the blood abnormalities of elderly Europeans with pernicious anemia 6. For example, the cytologic properties of the 2 anemias were identical, and both types responded well to crude liver extract.

However, only the tropical illness responded to yeast extract. Furthermore, although purified liver extract had proved effective in the treatment of pernicious anemia, it did not cure the tropical form 6. This hypothesis was subsequently verified.

Folic acid with or without vitamin B12 for cognition and dementia.

However, the identification of vitamin B as the anti—pernicious anemia factor in liver 7 followed the isolation of folic acid from yeast 8 by several years, during which time folic acid was administered in large doses to patients with pernicious anemia 9.

Because the inappropriateness of this treatment quickly became apparent, reports of cases thus treated in the late s and early s comprise the entire body of literature on the effect of folic acid administration on persons deficient for vitamin B 10 — Reviews of the historic case reports allude to rapid neurologic deterioration after improvement of anemia 10 Consequently, the idea has developed that excessive intake of folic acid can obscure or mask vitamin B deficiency and potentially delay its diagnosis until neurologic consequences become irreversible Food folic acid fortification and the debate on folic acid safety The move by the United States and other governments to fortify staple food products with folic acid for the prevention of neural tube defects rekindled the debate over the safety of folic acid for the elderly, who are at high risk of vitamin B deficiency.

The high degree of uncertainty led some to question the safety of fortification 1920 and inspired others to criticize the upper intake as too conservative 21 Particularly in light of continued demands for a higher level of fortification 2324clearly defining the benefits and risks of high folic acid intake assumes vital importance. For this reason trials of folic acid supplements may involve simultaneous administration of vitamin B Apparent benefit from folic acid given in the combination would therefore need to be "corrected" for any effect of vitamin B12 alone.

A separate Cochrane review of vitamin B12 and cognitive function is being prepared. To examine the effects of folic acid supplementation, with or without vitamin B12, on elderly healthy and demented people, in preventing cognitive impairment or retarding its progress.

All double-blind placebo-controlled randomized trials, in which supplements of folic acid with or without vitamin B12 were compared with placebo for elderly healthy people or people with any type of dementia or cognitive impairment. The reviewers independently applied the selection criteria and assessed study quality.

One reviewer extracted and analysed the data. In comparing intervention with placebo, weighted mean differences, and standardized mean difference or odds ratios were estimated. Four randomized controlled trials fulfilled the inclusion criteria for this review.

One trial Bryan enrolled healthy women, and three Fioravanti ; Sommer ; VITAL recruited people with mild to moderate cognitive impairment or dementia with or without diagnosed folate deficiency.

vitamin b12 and folate relationship counseling

One trial VITAL studied the effects of a combination of vitamin B12 and folic acid on patients with mild to moderate cognitive impairment due to Alzheimer's disease or mixed dementia. The analysis from the included trials found no benefit from folic acid with or without vitamin B12 in comparison with placebo on any measures of cognition and mood for healthy or cognitively impaired or demented people: Folic acid effect and healthy participants: Folic acid effect and people with mild to moderate cognitive decline or dementia: None of the sub tests of the Randt Memory Test RMT showed statistically significant benefit from 15 mg of folic acid orally per day for 9 weeks when compared with placebo.

There was no beneficial effect of mcg of folic acid per day on measures of cognition or mood in older healthy women.